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For regular coronary heart perform, look past the genes

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On the left, a mouse embryo is displaying enhancer exercise (blue staining) within the creating coronary heart. On the suitable, a closeup of this coronary heart, is displaying that the enhancer is lively within the left ventricle , left atrium, and proper atrium of the center. Credit score: Mammalian Useful Genomics Laboratory/Berkeley Lab Researchers have proven that when components of a genome often known as enhancers are lacking, the center works abnormally, a discovering that bolsters the significance of DNA segments as soon as thought of "junk" as a result of they don't code for particular proteins. The staff, led by scientists on the Division of Vitality's Lawrence Berkeley Nationwide Laboratory (Berkeley Lab), examined the position of two coronary heart enhancers within the mouse genome, displaying that the lack of both one resulted in signs that resemble human cardiomyopathy, a illness by which the center muscle typically turns into enlarge...

Calcium dietary supplements might injury the guts

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More than half of women over 60 take calcium supplements -- many without the oversight of a physician -- because they believe it will reduce their risk of osteoporosis, researchers estimate. Credit: © sasimoto / Fotolia After analyzing 10 years of medical tests on more than 2,700 people in a federally funded heart disease study, researchers at Johns Hopkins Medicine and elsewhere conclude that taking calcium in the form of supplements may raise the risk of plaque buildup in arteries and heart damage, although a diet high in calcium-rich foods appears be protective. In a report on the research, published Oct. 10 in the  Journal of the American Heart Association , the researchers caution that their work only documents an association between calcium supplements and atherosclerosis, and does not prove cause and effect. But they say the results add to growing scientific concerns about the potential harms of supplements, and they urge a consultation with a knowledgeab...